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The rate of GSH synthesis is dependent upon the availability of cysteine and the activity of the rate-limiting enzyme, -glutamylcysteine synthetase (also called glutamate-cysteine ligase, GCL)

In 2023, both were placed on a list of substances considered to be too high-risk for pharmacy compounding

Compounding this issue, certain mycotoxins have been shown in animal models to suppress the production of Diamine Oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine in the gut

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